For many people, the biggest barrier to regular health monitoring isn't cost or inconvenience; it's the fear of needles and the discomfort of traditional blood draws. HealthieOne solves this problem by delivering comprehensive health insights from a much smaller amount of blood using a painless, needle-free self- collection method.
What truly sets HealthieOne apart is the power of our proprietary technology: the ability to analyze over 250 health markers from just 1 mL of blood (two small vials). Conventional blood tests often require 100+ mL of blood drawn through multiple vials via painful venipuncture. This means you can gain deep insights into your cardiovascular health, metabolic function, hormone levels, nutritional status, and much more, all without the anxiety and discomfort of traditional blood draws.

The Accuracy and Reliability of Capillary vs. Venous Blood Collection 

Except for a few markers: Co2, Potassium and sodium, growing studies demonstrate that for the vast majority of biomarkers, capillary and venous samples yield comparable results, supporting at-home blood testing as a clinically viable alternative to traditional venipuncture.

Study 1: American Journal of Clinical Pathology (2021) [1]

  • Sample size: 59 paired capillary and venous specimens from 56 hospitalized patients
  • Analytes tested: Basic metabolic panel including calcium, carbon dioxide, chloride, potassium, sodium, creatinine, glucose, and serum urea nitrogen
  • Key finding: "Paired samples were comparable for all the analytes tested with the exception of bicarbonate and potassium" 
  • HealthieOne alignment: We exclude problematic analytes (potassium, CO₂) from our capillary testing panel and focus on biomarkers with proven equivalence

Study 2: Clinical Chemistry and Laboratory Medicine (2024/2025) [2]

  • Sample size: 188 adult patients
  • Analytes tested: 34 routine chemistry markers including ALT, albumin, ALP, apolipoprotein B, AST, bilirubin, calcium, chloride, creatine kinase, creatinine, CRP, ferritin, folic acid, free T4, GGT, glucose, HDL cholesterol, iron, lipase, Lp(a), magnesium, phosphate, potassium, PSA, sodium, total cholesterol, total protein, transferrin, triglycerides, TSH, urate, urea, vitamin B12, and vitamin D
  • Key finding: "Capillary and venous samples showed comparable results for almost all studied chemistry analytes" 
  • Success rate: 30 out of 33 analytes met Total Allowable Error (TEa) criteria; 28 of 29 met CLIA 2024 acceptance limits 
  • Conclusion: "Capillary blood draw is a suitable alternative for venous blood sampling for measuring most of the investigated analytes" 

Study 3: Journal of Applied Laboratory Medicine (2025) [3]

  • Focus: Validation of miniaturized assays for capillary specimens
  • Key finding: Demonstrated equivalence for broad diagnostic testing panels 
  • Innovation: Proved that smaller sample volumes maintain clinical accuracy 

Study 4: Analytical Chemistry (2024) [4]

  • Sample size: 20 healthy participants
  • Analytes tested: 112 lipoprotein subfraction parameters plus glycoprotein markers
  • Method: Self-administered 500 μL capillary collection compared to 10 mL venous blood draws
  • Key finding: “capillary lipoprotein, SPC, and Glyc concentrations follow changes in venous concentrations. These results indicate that capillary blood microsamples are suitable for sampling in remote areas and for high-frequency longitudinal sampling of the majority of lipoproteins, SPCs, and Glycs”

Study 5: Clinical Chemistry (2022) [5]

  • Sample size: 188 healthy volunteers and patients
  • Analytes tested: INR, prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), fibrinogen, and D-dimer
  • Key finding: "Strong correlations and acceptable variations, using the TEa as decision limit, were found for INR, PT, TT, fibrinogen, and D-dimer between capillary and venous sampling" 
  • Exception noted: APTT showed significant bias with capillary samples 
  • Conclusion: "Capillary blood sampling proved to be an alternative blood withdrawal method for routine coagulation assays, with the exception of APTT" 

Study 6: Journal of Molecular and Cellular Lipidology (2025) [6]

  • Sample size: 10 male subjects with paired samples
  • Method: High-resolution mass spectrometry-based lipidomics
  • Key finding: Linear regression showed near-perfect concordance (r = 0.95–0.99) between capillary and venous blood plasma lipidomes 
  • Statistical analysis: Comprehensive PCA showed no significant difference (adjusted P-value > 0.05) in lipid composition 
  • Conclusion: "The capillary and venous blood plasma lipidomes are essentially identical making self-administered collection of capillary blood a viable approach for clinical blood plasma lipidomics" 

Study 7: Metabolomics (2023) [7]

  • Sample size: 22 healthy subjects
  • Comparison: Capillary blood, venous blood, and plasma collected via volumetric absorptive microsampling (VAMS)
  • Key finding: Capillary blood samples can capture biological differences of interest, representing "a valid and interesting sample collection procedure" for metabolomics 
  • HealthieOne alignment: Supports minimally invasive sampling for comprehensive metabolic profiling

Study 8: Metabolomics (2018) [8]

  • Sample size: 5 healthy volunteers (pilot study)
  • Analytes tested: 45 clinically-relevant metabolites including amino acids, energy-related metabolites (glycolytic and Krebs cycle intermediates), acyl-carnitines, and bile acids
  • Key finding: TAP-derived capillary blood is a "logistically-friendly source of blood for large scale metabolomics studies" 
  • Particularly strong concordance: Amino acids, glycemia, lactatemia, bile acids, and acyl-carnitine levels 

The Bottom Line

The HealthieOne test represents more than technological innovation, it's a transformation in how we approach health monitoring. By eliminating the pain and inconvenience of traditional blood collection while maintaining clinical accuracy, we open the door to more frequent, comprehensive health assessments that can truly impact long-term wellbeing.
Learn more about The Science Behind HealthieOne and Why CLIA and CAP Certifications Matter: The Gold Standard in Laboratory Testing.

References

[1] Ganti L, et al. Preanalytical Challenges During Capillary Fingerstick Sampling Preclude Its Widespread Use in Adult Hospitalized Patients. Am J Clin Pathol. 2021;155(2):193-197. doi:10.1093/ajcp/aqaa138 

[2] Doeleman MJH, et al. Comparison of capillary finger stick and venous blood sampling for 34 routine chemistry analytes: potential for in hospital and remote blood sampling. Clin Chem Lab Med. 2025;63(4):747-752. doi:10.1515/cclm-2024-0812 

[3] Journal of Applied Laboratory Medicine. Equivalence between Capillary Blood and Venous Blood Test Results Using Miniaturized Assays and Novel Collection Methods to Support Routine Bloodwork. 2025. https://www.researchgate.net/publication/391874025 

[4] Gray N, et al. Rapid and Self-Administrable Capillary Blood Microsampling Demonstrates Statistical Equivalence with Standard Venous Collections in NMR-Based Lipoprotein Analysis. Anal Chem. 2024;96(11):4505-4513. doi:10.1021/acs.analchem.3c05152

[5] Poland DCW, et al. Comparison of capillary and venous blood sampling for routine coagulation assays. Clin Chim Acta. 2022;528:51-56. doi:10.1016/j.cca.2022.01.015

[6] Muller L, et al. Comparison of the capillary and venous blood plasma lipidomes: validation of self-collected blood for plasma lipidomics. J Mol Cell Lipidol. 2025. https://pmc.ncbi.nlm.nih.gov/articles/PMC11932689/ 

[7] Volani C, et al. VAMS-Based Blood Capillary Sampling for Mass Spectrometry-Based Human Metabolomics Studies. Metabolites. 2023;13(2):285. doi:10.3390/metabo13020285 

[8] Catala A, et al. Quantitative metabolomics comparison of traditional blood draws and TAP capillary blood collection. Metabolomics. 2019;15(1):7. doi:10.1007/s11306-018-1466-1